Findings

What do systematic reviews say?

2,359 questions · 2,491 findings · 249 reviews

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No studies found 696 · 27.9%GRADE not reported 213 · 8.6%Very low 611 · 24.5%Low 595 · 23.9%Moderate 315 · 12.6%High 61 · 2.4%

Physical activity vs no physical activity

Change in VO2 peak during maximal exercise · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 348 participants
Moderate

Physical activity vs no physical activity

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 367 participants
Low

Physical activity vs no physical activity

HRQoL score (physical functioning) (change from baseline) · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 247 participants
Low

Physical activity vs no physical activity

QoL (CFQ‐R) Respiratory domain · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 251 participants
Low

Physical activity vs no physical activity

Pulmonary exacerbations · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
High

Physical activity vs no physical activity

Diabetic control · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 91 participants
Moderate

Physical activity vs no physical activity

Adverse events: number of adverse events Active intervention: 12 months · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 156 participants
Low

Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines 2022 · Cochrane Headline outcomes only
RR 0.92 [0.84, 1.01]
1 study · 200 participants
Low

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Serum high-sensitivity C-reactive protein (hs-CRP) · Patients with cardiovascular disease and chronic periodontitis

1 finding from 1 review

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes
12 months
Serum hs-CRP tested at one year; as loss to follow-up was almost 90%, data not considered useful for analysis (no usable estimate).
1 study · 37 participants
GRADE not reported

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

CRP (mg/dL) at end of study · People with periodontitis and metabolic syndrome (no CVD; primary prevention)

1 finding from 1 review

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes
12 months
beta coefficient -0.002 [-0.19, 0.20]
1 study
Very low

Transurethral microwave thermotherapy vs sham

Erectile function · men with lower urinary tract symptoms secondary to benign prostatic obstruction

1 finding from 1 review

Transurethral microwave thermotherapy for the treatment of lower urinary tract symptoms in men with benign prostatic… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 375 participants
Very low

Transurethral microwave thermotherapy vs sham

Ejaculatory function · men with lower urinary tract symptoms secondary to benign prostatic obstruction

1 finding from 1 review

Transurethral microwave thermotherapy for the treatment of lower urinary tract symptoms in men with benign prostatic… 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 727 participants
Very low

Transurethral microwave thermotherapy vs transurethral resection of the prostate

Erectile function · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Transurethral microwave thermotherapy showed no clear difference in erectile function (sexually‐active men only) compared with transurethral resection of the prostate (low certainty).

1 finding from 1 review

Transurethral microwave thermotherapy for the treatment of lower urinary tract symptoms in men with benign prostatic… 2021 · Cochrane Headline outcomes only
RR 0.63 [0.24, 1.63]
5 studies · 337 participants
Low

Transurethral microwave thermotherapy vs transurethral resection of the prostate

Ejaculatory function · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Transurethral microwave thermotherapy may leads to lower ejaculatory function (sexually‐active men only) compared with transurethral resection of the prostate (low certainty).

1 finding from 1 review

Transurethral microwave thermotherapy for the treatment of lower urinary tract symptoms in men with benign prostatic… 2021 · Cochrane Headline outcomes only
RR 0.36 [0.24, 0.53]
4 studies · 241 participants
Low

Interventions delivered by dental professionals vs control

Smoking cessation · participants who used tobacco products

It is very uncertain whether interventions delivered by dental professionals changes multi‐session behavioural support versus usual care, brief advice,… compared with control (very low certainty).

1 finding from 1 review

Interventions for tobacco cessation delivered by dental professionals 2021 · Cochrane Headline outcomes only
RR 1.9 [1.17, 3.11]
7 studies · 2639 participants
Very low

Intervention not reported

% of participants physically active [ · children and adolescents aged 6 to 18 years

1 finding from 1 review

School‐based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6… 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 6068 participants
Very low

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Infection or inflammation at individual level (as measured by urinary neopterin, C‐reactive protein or alpha‐1‐acid glycoprotein variant A) · general population of all age groups (including pregnant women) from any country, over two years of age

1 finding from 1 review

Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in… 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Infection or inflammation at individual level as measured by C‐reactive protein (CRP) (only in children 2 to 11 years of age) · general population of all age groups (including pregnant women) from any country, over two years of age

1 finding from 1 review

Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 558 participants
Moderate

Kinesiotaping vs other conservative treatment

Active range of motion (shoulder abduction) without pain. Scale: 0 to 180 degrees№ of participants: 143(3 RCTs) · rotator cuff disease

1 finding from 1 review

Kinesio taping for rotator cuff disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Kinesiotaping vs sham taping

Active range of motion (shoulder abduction) without pain. Scale: 0 to 180 degrees№ of participants: 143(3 RCTs) · rotator cuff disease

1 finding from 1 review

Kinesio taping for rotator cuff disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low