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Evidence found and GRADE certainty

504 questions · 511 findings · 66 reviews

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No studies found 104 · 20.4%GRADE not reported 26 · 5.1%Very low 107 · 20.9%Low 129 · 25.2%Moderate 107 · 20.9%High 38 · 7.4%

Intervention not reported

Total studies: 93 Total participants: 22,558 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…

The intervention led to lower total studies: 93 Total participants: 22,558; GRADE not reported.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who successfully completed neurodiagnostic… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Number of children with clinical adverse event: oxygen desaturation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: desaturation compared with sodium thiopental rectal (25 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Number of children with clinical adverse event: diarrhoea · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to lower number of children with clinical adverse event: diarrhoea compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review