Botulinum toxin type A vs placebo
Cervical dystonia‐specific improvement · cervical dystonia
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Findings
What do systematic reviews say?
4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only
No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%
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Botulinum toxin type A vs placebo
Adverse events at 4 weeks; 1085 participants (8 RCTs) · cervical dystonia
Botulinum toxin type A probably leads to higher adverse events at 4 weeks; 1085 participants (8 RCTs) compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.23 [1.05, 1.43]Studies not reportedModerate
Botulinum toxin type A vs placebo
Subjective participant assessment at 4 weeks; 755 participants(6 RCTs) · cervical dystonia
Botulinum toxin type A leads to higher subjective participant assessment at 4 weeks; 755 participants(6 RCTs) compared with placebo (high certainty).
1 finding from 1 review
- RR 2.19 [1.78, 2.7]Studies not reportedHigh
Botulinum toxin type A vs placebo
Cervical dystonia‐specific pain · cervical dystonia
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Botulinum toxin type A vs placebo
Tolerability assessed as dropouts at 4 to 6 weeks: 705 participants (5 RCTs) · cervical dystonia
Botulinum toxin type A leads to lower tolerability assessed as dropouts at 4 to 6 weeks: 705 participants… compared with placebo (high certainty).
1 finding from 1 review
- RR 0.48 [0.32, 0.73]Studies not reportedHigh
Botulinum toxin type A vs placebo
Health‐related quality of life · cervical dystonia
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Botulinum toxin type A vs placebo
Duration of effect 618 participants (5 RCTs) · cervical dystonia
It is very uncertain whether botulinum toxin type A changes duration of effect 618 participants (5 RCTs) compared with placebo (very low certainty).
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Presurgical medical therapy vs Placebo or no active treatment
Pelvic pain · women having endometriosis surgery
The review found no eligible studies for this question.
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Postsurgical medical therapy vs Placebo or no active treatment
Recurrence · women having endometriosis surgery
Postsurgical medical therapy may leads to lower disease recurrence ≤ 12 months (dichotomous) compared with placebo or no medical therapy (low certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 0.3 [0.17, 0.54]4 studies · 433 participantsLow
Postsurgical medical therapy vs Placebo or no active treatment
Disease recurrence ≤ 12 months (EEC stage) · women having endometriosis surgery
It is very uncertain whether postsurgical medical therapy changes disease recurrence ≤ 12 months (EEC stage) compared with placebo or no medical therapy (very low certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 0.88 [0.67, 1.15]1 study · 285 participantsVery low
Postsurgical medical therapy vs Placebo or no active treatment
Pregnancy rate · women having endometriosis surgery
Postsurgical medical therapy probably leads to higher pregnancy rate (dichotomous) compared with placebo or no medical therapy (moderate certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 1.19 [1.02, 1.38]11 studies · 955 participantsModerate
Presurgical medical therapy vs Placebo or no active treatment
Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery
It is very uncertain whether presurgical medical therapy changes pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with placebo or no medical therapy (very low certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 1.1 [0.72, 1.66]1 study · 262 participantsVery low
Presurgical medical therapy vs Placebo or no active treatment
Disease recurrence at 3 months – total (AFS score) · women having endometriosis surgery
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 80 participantsVery low
Presurgical medical therapy vs Placebo or no active treatment
Recurrence · women having endometriosis surgery
The review found no eligible studies for this question.
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Presurgical medical therapy vs Placebo or no active treatment
Disease recurrence ≤ 12 months (EEC stage) · women having endometriosis surgery
It is very uncertain whether presurgical medical therapy changes disease recurrence ≤ 12 months (EEC stage) compared with placebo or no medical therapy (very low certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 1.11 [0.86, 1.43]1 study · 262 participantsVery low
Presurgical medical therapy vs Placebo or no active treatment
Pregnancy rate · women having endometriosis surgery
It is very uncertain whether presurgical medical therapy changes pregnancy rate (dichotomous) compared with placebo or no medical therapy (very low certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 1.18 [0.97, 1.45]1 study · 262 participantsVery low
Postsurgical medical therapy vs Placebo or no active treatment
Pelvic pain · women having endometriosis surgery
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 340 participantsVery low
Postsurgical medical therapy vs Placebo or no active treatment
Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery
Postsurgical medical therapy may leads to lower pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with placebo or no medical therapy (low certainty).
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyRR 0.7 [0.52, 0.94]5 studies · 657 participantsLow
Postsurgical medical therapy vs Placebo or no active treatment
Disease recurrence at 12 months – total (AFS score) · women having endometriosis surgery
1 finding from 1 review
- Pre‐ and postsurgical medical therapy for endometriosis surgery 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 53 participantsVery low
Antidepressants vs placebo
Depression: meeting study criteria for depression at end of · people with stroke
It is very uncertain whether pharmacological interventions (antidepressants) changes depression: meeting study criteria for depression at end treatment… compared with placebo (very low certainty).
1 finding from 1 review
- Pharmacological, psychological and non‐invasive brain stimulation interventions for preventing depression after stroke 2020 · Cochrane Headline outcomes onlyRR 0.5 [0.37, 0.68]9 studies · 734 participantsVery low