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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

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No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Phlebotonics vs placebo?

Oedema in the lower legs (dichotomous variable) · patients with venous insufficiency

Do phlebotonics improve signs and symptoms of venous insufficiency… probably leads to lower oedema in the lower legs (dichotomous variable) compared with placebo? (moderate certainty).

1 finding from 1 review

Phlebotonics vs placebo?

Ulcer healing · patients with venous insufficiency

Do phlebotonics improve signs and symptoms of venous insufficiency… showed no clear difference in ulcer healing (dichotomous variable) compared with placebo? (low certainty).

1 finding from 1 review

Phlebotonics vs placebo?

Adverse events · patients with venous insufficiency

Do phlebotonics improve signs and symptoms of venous insufficiency… probably leads to higher adverse events compared with placebo? (moderate certainty).

1 finding from 1 review

IVIg vs placebo

Death · adults with renal vasculitis

Intravenous immunoglobulin showed no clear difference in death compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo

Response at 3 months · adults with renal vasculitis

Intravenous immunoglobulin may leads to higher response at 3 months compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo

Relapse at 3 months · adults with renal vasculitis

Intravenous immunoglobulin showed no clear difference in relapse at 3 months compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo

Adverse events · adults with renal vasculitis

Intravenous immunoglobulin may leads to higher adverse events compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Death at 6 months · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in death at 6 months compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Remission · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in remission at one year compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Discontinuation of medication due to adverse events · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in adverse events causing study drug discontinuation compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Urinary tract infection · adults with renal vasculitis for maintenance therapy

Antibiotics may leads to lower infection (urinary tract infection) compared with placebo (low certainty).

1 finding from 1 review