Findings

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Abiraterone + ADT vs ADT only

Adverse events grade 3 to 5 Range of · men with metastatic, hormone‐sensitive prostate cancer

Abiraterone + ADT leads to higher grades III to V adverse events (severe and life threatening, as per… compared with ADT alone (high certainty).

1 finding from 1 review

Abiraterone + ADT vs ADT only

Time to death from prostate cancerMedian · men with metastatic, hormone‐sensitive prostate cancer

Abiraterone + ADT probably leads to lower time to death due to prostate cancer measured at a median compared with ADT alone (moderate certainty).

1 finding from 1 review

Abiraterone + ADT vs ADT only

Discontinued treatment due to adverse events measured at a median · men with metastatic, hormone‐sensitive prostate cancer

Abiraterone + ADT probably leads to higher discontinued treatment due to adverse events measured at a median compared with ADT alone (moderate certainty).

1 finding from 1 review

Behavioural activation vs interpersonal, cognitive analytic, integrative

treatment acceptabilityup to 6 months (4‐12 weeks) · depression in adults

It is very uncertain whether behavioural activation changes treatment acceptabilityup to 6 months (4‐12 weeks) compared with interpersonal, cognitive analytic, integrative (very low certainty).

1 finding from 1 review