Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

517 questions · 551 findings · 17 reviews · All outcomes

No studies found 65 · 11.8%GRADE not reported 419 · 76%Very low 29 · 5.3%Low 25 · 4.5%Moderate 13 · 2.4%High 0 · 0%

Chlorhexidine mouthwash vs Salt and soda mouthwash

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Chlorhexidine mouthwash showed no clear difference in time to heal mucositis (days) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Ketoconazole vs placebo

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Ketoconazole (absorbed from GI tract) showed no clear difference in mycological: eradication of oral candidiasis compared with placebo; GRADE not reported.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in time to heal mucositis (days) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Clotrimazole (partially absorbed from GI tract) vs placebo

Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Clotrimazole (partially absorbed from GI tract) showed no clear difference in clinical: eradication of oral candidiasis compared with placebo; GRADE not reported.

1 finding from 1 review

Therapist support (visits) vs control (e.g. usual activities)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Therapist support (visits) showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review

Fluconazole (absorbed from GI tract) vs Itraconazole

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Fluconazole (absorbed from GI tract) led to higher mycological: eradication of oral candidiasis compared with itraconazole (absorbed from GI tract); GRADE not reported.

1 finding from 1 review

Chlorhexidine mouthwash vs Salt and soda mouthwash

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Chlorhexidine mouthwash showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Mucositis severity (mild to moderate) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Low level laser therapy led to higher mucositis severity (mild to moderate) compared with sham (placebo) laser treatment; GRADE not reported.

1 finding from 1 review

GM-CSF vs placebo or no treatment

Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Granulocyte macrophage-colony stimulating factor (GM-CSF) led to higher improvement in mucositis compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

GM-CSF vs placebo or no treatment

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Granulocyte macrophage-colony stimulating factor (GM-CSF) showed no clear difference in time to heal mucositis (days) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

CBT vs control (e.g. usual activities)

Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Cognitive behavioural therapy showed no clear difference in daily mean opiate intake per hour compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review

Morphine via patient-controlled analgesia (PCA) vs Morphine via continuous infusion (CI)

Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine via patient-controlled analgesia (PCA) led to lower daily mean opiate intake per hour compared with morphine via continuous infusion (CI); GRADE not reported.

1 finding from 1 review

CBT vs control (e.g. usual activities)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Cognitive behavioural therapy showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review