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Evidence found and GRADE certainty

628 questions · 651 findings · 39 reviews · Skin

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No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%

Metronidazole vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Metronidazole probably leads to higher physician‐assessed improvement in rosacea severity compared with placebo (moderate certainty).

1 finding from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Proportion of participants with adverse event · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel probably leads to higher proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Assessment of erythema or telangiectasia · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel showed no clear difference in assessment of erythema or telangiectasia compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Tetracycline showed no clear difference in participant‐assessed improvement in rosacea severity compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Proportion of participants with adverse event · Participants with rosacea

Tetracycline showed no clear difference in proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review

Tetracycline vs placebo

Time needed until improvement of the skin lesions · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review