Findings

What do systematic reviews say?

480 questions · 559 findings · 16 reviews · Endodontics and dental trauma

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No studies found 75 · 13.4%GRADE not reported 394 · 70.5%Very low 39 · 7%Low 36 · 6.4%Moderate 14 · 2.5%High 1 · 0.2%

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
Vital bacterial counts decreased after the active intervention (MTAD) but live bacteria were present in all of the samples; no further usable data reported.
1 study
GRADE not reported

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

Sodium hypochlorite 5.25% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with sodium hypochlorite 5.25% with hydrogen peroxide 3%; GRADE not reported.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
RR 1.22 [0.4, 4.2]
1 study · 167 participants
GRADE not reported

Intervention not reported

Clinical and radiographic success rate

1 finding from 1 review

Partial pulpotomy for carious pulp exposure in adult mature permanent teeth: a systematic review and meta-analysis. 2025 All outcomes
Full meta-regression: preoperative diagnosis
Meta-regression No significant association
Studies not reported
GRADE not reported

Intervention not reported

Tooth survival

The review found no eligible studies for this question.

1 finding from 1 review

The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital permanent teeth… 2025 All outcomes
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no estimate extracted
0 studies
No studies found

Intervention not reported

Clinical and radiographic success rate

1 finding from 1 review

Partial pulpotomy for carious pulp exposure in adult mature permanent teeth: a systematic review and meta-analysis. 2025 All outcomes
Full meta-regression: follow-up duration
Meta-regression No significant association
Studies not reported
GRADE not reported