Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Event‐free survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

High‐dose chemotherapy followed by autologous haematopoietic cell… showed no clear difference in event‐free survival (reported as number of participants with… compared with conventional chemotherapy plus whole lung irradiation (low certainty).

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Overall survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Quality‐adjusted survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Toxicity · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Progression‐free survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs control

Symptomatic catheter‐related thrombosis (up to 3 months) · children with a CVC

Does low molecular weight heparin prevent central venous… showed no clear difference in symptomatic CVC‐related thrombosis ( compared with control (low certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review