Cochrane · systematic review · CD011405
High‐dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma
Haveman, LM, van Ewijk, R, van Dalen, EC, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Childhood CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
1
No studies
4
Included studies
NR
No studies 4 · 80%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
High‐dose chemotherapy followed by autologous haematopoietic cell transplantation compared with conventional chemotherapy plus whole lung irradiation
Population: children, adolescents, and young adults with primary metastatic Ewing sarcoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Event‐free survival (reported as number of participants with progression, relapse, second malignancy, or death, whatever the cause) High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation | HR 0.83 [0.59, 1.17] | 1 study · 267 participants | Low Downgraded: risk of bias |
Overall survival High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation | no estimate extracted | NR | No studies |
Quality‐adjusted survival High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation | no estimate extracted | NR | No studies |
Toxicity High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation | no estimate extracted | NR | No studies |
Progression‐free survival High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation | no estimate extracted | NR | No studies |