Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,057 questions · 1,077 findings · 32 reviews · Skin

No studies found 395 · 36.7%GRADE not reported 89 · 8.3%Very low 172 · 16%Low 177 · 16.4%Moderate 191 · 17.7%High 53 · 4.9%

Acyclovir + calamine + cetirizine vs calamine + cetirizine

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir + calamine + cetirizine may leads to higher the proportion of participants with resolution of itch within 2… compared with calamine + cetirizine (low certainty).

1 finding from 1 review

Clarithromycin vs placebo

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Clarithromycin showed no clear difference in the proportion of participants with resolution of itch within 2… compared with placebo (moderate certainty).

1 finding from 1 review

Acyclovir + calamine + cetirizine vs calamine + cetirizine

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Headache. · pityriasis rosea

Acyclovir + calamine + cetirizine showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with calamine + cetirizine (low certainty).

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir showed no clear difference in the proportion of participants with resolution of itch within 2… compared with erythromycin (low certainty).

1 finding from 1 review

Acyclovir vs erythromycin

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea
1 finding from 1 review

Clarithromycin vs placebo

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Clarithromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Clarithromycin showed no clear difference in the proportion of participants with good or excellent rash… compared with placebo (moderate certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Erythromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Erythromycin vs placebo

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review