Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

660 questions · 679 findings · 99 reviews · Headline outcomes only

No studies found 160 · 23.6%GRADE not reported 17 · 2.5%Very low 199 · 29.3%Low 189 · 27.8%Moderate 97 · 14.3%High 17 · 2.5%

Extended‐fixed vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in endophthalmitis (ocular adverse event) compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

As needed may leads to lower gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Central retinal thickness μm (CRT) change at 1 year The aim of treatment is to reduce central retinal thickness so thinner is better. · people with neovascular age‐related macular degeneration
1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

As needed probably leads to lower endophthalmitis (ocular adverse event) compared with monthly injections (moderate certainty).

1 finding from 1 review

Extended‐fixed vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (moderate certainty).

1 finding from 1 review