Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

469 questions · 483 findings · 63 reviews

No studies found 117 · 24.2%GRADE not reported 13 · 2.7%Very low 68 · 14.1%Low 141 · 29.2%Moderate 112 · 23.2%High 32 · 6.6%

E1B‐deleted (dl1520) adenovirus vs percutaneous alcohol injection

Adverse events considered non‐serious · participants with unresectable hepatocellular carcinoma

It is very uncertain whether E1B‐deleted (dl1520) adenovirus changes adverse events considered non‐serious (number of participants) compared with percutaneous ethanol injection (very low certainty).

1 finding from 1 review

Adenovirus‐thymidine kinase with ganciclovir (ADV‐TK/GCV) plus liver transplantation vs liver transplantation

All‐cause mortality · participants with unresectable hepatocellular carcinoma

It is very uncertain whether adenovirus‐thymidine kinase with ganciclovir (ADV‐TK/GCV) plus liver… changes all‐cause mortality compared with liver transplantation (very low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic black or African American

6‐Month abstinence ‐ homozygous major · people who smoke

Active NRT leads to higher abstinence at 6 months ‐ homozygous major compared with placebo ‐ rs16969968 ‐ non‐Hispanic black or African American (high certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic black or African American

6‐Month abstinence ‐ heterozygous or homozygous minor · people who smoke

Active NRT showed no clear difference in abstinence at 6 months ‐ heterozygous or homozygous minor compared with placebo ‐ rs16969968 ‐ non‐Hispanic black or African American (low certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic black or African American

Abstinence · people who smoke

Active NRT showed no clear difference in abstinence at end of treatment compared with placebo ‐ rs16969968 ‐ non‐Hispanic black or African American (moderate certainty).

2 findings from 1 review

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic black or African American

Abstinence at end of treatment ‐ homozygous major · people who smoke

Active NRT leads to higher abstinence at end of treatment ‐ homozygous major compared with placebo ‐ rs16969968 ‐ non‐Hispanic black or African American (high certainty).

1 finding from 1 review

Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic black or African American

Abstinence at end of treatment ‐ heterozygous or homozygous minor · people who smoke

Active NRT probably leads to lower abstinence at end of treatment ‐ heterozygous or homozygous minor compared with placebo ‐ rs16969968 ‐ non‐Hispanic black or African American (moderate certainty).

1 finding from 1 review