Histologic remission · Adult patients with active ulcerative colitis
Budesonide MMX® 9 mg may leads to higher histologic remission compared with placebo (low certainty).
1 finding from 1 review
Endoscopic remission · Adult patients with active ulcerative colitis
Budesonide MMX® 9 mg probably leads to higher endoscopic remission compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · Adult patients with active ulcerative colitis
Budesonide MMX® 9 mg showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Adverse events · Adult patients with active ulcerative colitis
Budesonide MMX® 9 mg showed no clear difference in adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Remission (combined clinical and endoscopic remission) · Adult patients with active ulcerative colitis
Budesonide MMX® 6 mg showed no clear difference in remission (combined clinical and endoscopic remission compared with placebo (low certainty).
1 finding from 1 review
Clinical improvement · Adult patients with active ulcerative colitis
Budesonide MMX® 6 mg showed no clear difference in clinical improvement compared with placebo (low certainty).
1 finding from 1 review
Neural tube defects (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate leads to lower neural tube defects (All) compared with no intervention, placebo or other micronutrients without folate… (high certainty).
1 finding from 1 review
Miscarriage · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).
1 finding from 1 review
Cleft lip (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in cleft lip (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Cleft palate (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in cleft palate (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Congenital cardiovascular anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in congenital cardiovascular anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Other congenital anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in other congenital anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Neonatal mortality · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Maternal anaemia at or near term (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Maternal red blood cell folate at or near term (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Serum folate at or near term · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Low birthweight · Women receiving supplements in pregnancy
Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).
1 finding from 1 review
Participants with at least some Side Effects · Women receiving supplements in pregnancy
It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).
1 finding from 1 review
Severe anaemia at any time during second and third trimester (Hb less than 70 g/L) · Women receiving supplements in pregnancy
1 finding from 1 review
Maternal clinical malaria or other infection in pregnancy · Women receiving supplements in pregnancy
Any intermittent iron regimen (with or without other vitamins and… led to lower maternal clinical malaria or other infection in pregnancy compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.
1 finding from 1 review