Dexmedetomidine showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 261 participants
Low

Dexmedetomidine vs control or placebo medications

Hypotension · adults undergoing brain surgery

Dexmedetomidine may leads to lower adverse event hypotension (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 184 participants
Low

Pregabalin or Gabapentin vs control or placebo medications

Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 202 participants
Low

Pregabalin or Gabapentin vs control or placebo medications

Acute postoperative pain at 12 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low

Pregabalin or Gabapentin vs control or placebo medications

Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 202 participants
Low

Pregabalin or Gabapentin vs control or placebo medications

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 202 participants
Low

Pregabalin or Gabapentin vs control or placebo medications

Additional analgesia required (escape analgesia) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 234 participants
Low

Pregabalin or Gabapentin vs control or placebo medications

Analgesic Success · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pregabalin or Gabapentin vs control or placebo medications

Adverse effects: 1. Sedation · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs control or placebo medications

Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 742 participants
High

Pregabalin or Gabapentin vs control or placebo medications

Chronic Headache · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
54 participants
Very low

Pregabalin or Gabapentin vs control or placebo medications

Length of critical care stay (hours) · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pregabalin or Gabapentin vs control or placebo medications

Length of hospital stay · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low

Pregabalin or Gabapentin vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Pregabalin or Gabapentin may leads to lower adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 273 participants
Low

Acetaminophen vs control or placebo medications

Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 332 participants
Moderate