Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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BoNT‐A vs sham

Observational gait analysis (improvement) · children with CP

BoNT‐A probably leads to higher observational gait analysis (improvement) compared with placebo or sham (moderate certainty).

2 findings from 1 review

BoNT‐A vs sham

Function · children with CP
3 findings from 1 review

BoNT‐A vs sham

Range of motion (passive ankle dorsiflexion) · children with CP
3 findings from 1 review

BoNT‐A vs sham

Satisfaction · children with CP
3 findings from 1 review

BoNT‐A vs sham

Spasticity (ankle plantarflexors) · children with CP
3 findings from 1 review

BoNT‐A vs sham

Adverse events · children with CP

BoNT‐A showed no clear difference in adverse events compared with placebo or sham (moderate certainty).

3 findings from 1 review

BoNT‐A vs sham

Instrumented gait analysis (kinematics) (not measured) · children with CP

The review found no eligible studies for this question.

2 findings from 1 review

BoNT‐A vs serial casting

Instrumented gait analysis (peak ankle dorsiflexion in stance) · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Observational gait analysis · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Function · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Satisfaction (not measured) · children with CP

The review found no eligible studies for this question.

3 findings from 1 review

BoNT‐A vs serial casting

Spasticity (ankle plantarflexors) · children with CP
3 findings from 1 review

BoNT‐A vs serial casting

Adverse events · children with CP

BoNT‐A showed no clear difference in adverse events compared with serial casting (low certainty).

3 findings from 1 review