Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS –lidocaine vs bupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS –lidocaine vs bupivacaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs 2‐chloroprocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine showed no clear difference in presence of any TNS – lidocaine vs 2‐chloroprocaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs levobupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs levobupivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs mepivacaine · adults undergoing surgery

It is very uncertain whether risk of transient neurological symptoms with spinal lidocaine changes presence of any TNS – lidocaine vs mepivacaine compared with other local anaesthetic (very low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs prilocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs prilocaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs procaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs procaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs ropivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs ropivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Intensive counseling vs usual family planning care

Rate of discontinuation due to menstrual disturbances · Women of reproductive age seeking to avoid pregnancy

Intensive counseling may leads to lower rate of discontinuation due to menstrual disturbances compared with usual family planning care (low certainty).

1 finding from 1 review

Intensive counseling vs usual family planning care

Rate of discontinuation due to all other adverse events · Women of reproductive age seeking to avoid pregnancy

Intensive counseling showed no clear difference in rate of discontinuation due to all other adverse events compared with usual family planning care (low certainty).

1 finding from 1 review

Intervention not reported

Death · children with severe malaria

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review

Intervention not reported

Fever clearance time · adults with severe malaria
1 finding from 1 review

Intervention not reported

Death · adults with severe malaria

The intervention probably leads to higher death (moderate certainty).

1 finding from 1 review

Intervention not reported

Coma resolution time · adults with severe malaria
1 finding from 1 review

Intervention not reported

Neurological sequelae at discharge · adults with severe malaria
1 finding from 1 review

Intervention not reported

Parasite clearance time · adults with severe malaria
1 finding from 1 review

Intervention not reported

Fever clearance time · adults with severe malaria
1 finding from 1 review

Intervention not reported

Coma resolution time · children with severe malaria
1 finding from 1 review