Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Rufinamide vs placebo

Frequency of adverse effects ‐ dizziness ( · people with drug‐resistant focal epilepsy

Rufinamide probably leads to higher adverse effects: dizziness compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall BPSD (multidomain) – not assessed · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Agitation · dementia
1 finding from 1 review

Intervention not reported

Depression – assessed in one study as "withdrawn behaviours" which included a lack of interest and sad mood · dementia
1 finding from 1 review

Intervention not reported

Anxiety ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Dropouts ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Final height and change in height · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects Oral glucose tolerance test (mg/dL) (at one year) · people with thalassaemia (any age)
1 finding from 1 review

Intervention not reported

Height SDS(at one year) · people with thalassaemia (any age)
1 finding from 1 review

Intervention not reported

Change in height SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)
1 finding from 1 review

Intervention not reported

Height velocity (cm/year) · people with thalassaemia (any age)
1 finding from 1 review

Intervention not reported

Change in height velocity SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)
1 finding from 1 review