SSA (3 RCTs; 586 participants)
Estimates of effects, ranking, and certainty of evidence for… probably leads to lower SSA (3 RCTs; 586 participants) compared with placebo (moderate certainty).
4 findings from 1 review
HR 0.51 [0.34, 0.77]
3 studies · 586 participants
Moderate
OR 2.93 [1.36, 6.32]
7 studies · 796 participants
Moderate
HR 0.34 [0.16, 0.76]
5 studies · 492 participants
High
Show 1 more finding
Total studies: 11 Total participants: 1338
1 finding from 1 review
no estimate extracted
11 participants
GRADE not reported
177‐Lu‐DOTATATE + SSA (1 RCT; 229 participants)
It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes 177‐Lu‐DOTATATE + SSA (1 RCT; 229 participants) compared with placebo (very low certainty).
2 findings from 1 review
Surufatinib (1 RCT; 198 participants)
Estimates of effects, ranking, and certainty of evidence for… probably leads to higher surufatinib (1 RCT; 198 participants) compared with placebo (moderate certainty).
2 findings from 1 review
Streptozocin + 5‐FU (1 RCT; 20 participants)
It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes streptozocin + 5‐FU (1 RCT; 20 participants) compared with placebo (very low certainty).
1 finding from 1 review
OR 0.13 [0, 4.58]
1 study · 5 participants
Very low
Total studies: 9 Total participants: 1311Â
1 finding from 1 review
no estimate extracted
9 participants
GRADE not reported
FVC (% predicted) Change from baseline · people with Duchenne muscular dystrophy and progressive respiratory decline
1 finding from 1 review
Frequency of hospitalisation for respiratory infection · people with Duchenne muscular dystrophy and progressive respiratory decline
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life Assessed by: Pediatric Quality of Life Inventory, change from baseline (0 to 100; 0 = worst outcome, 100 = best outcome) · people with Duchenne muscular dystrophy and progressive respiratory decline
1 finding from 1 review
Serious adverse events · people with Duchenne muscular dystrophy and progressive respiratory decline
Idebenone showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Non‐serious adverse events · people with Duchenne muscular dystrophy and progressive respiratory decline
Idebenone showed no clear difference in non‐serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Pain (PIPP) · neonates with mechanical ventilation
1 finding from 1 review
Duration of mechanical ventilation · neonates with mechanical ventilation
1 finding from 1 review
Neonatal mortality · neonates with mechanical ventilation
Opioids showed no clear difference in neonatal mortality compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Mortality before hospital discharge · neonates with mechanical ventilation
Opioids showed no clear difference in mortality to discharge compared with placebo or no treatment (low certainty).
1 finding from 1 review
Neurodevelopmental outcomes · neonates with mechanical ventilation
It is very uncertain whether opioids changes neurodevelopmental outcomes (18 to 24 months) compared with placebo or no treatment (very low certainty).
3 findings from 1 review
Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review
Adverse event: lead failure/ displacement · adults with chronic pain
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Adverse events: need for reoperation/ reimplantation · adults with chronic pain
The review found no eligible studies for this question.
3 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Participant‐reported pain relief of 50% or greater · adults with chronic pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found