Findings

What do systematic reviews say?

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Intervention not reported

Adverse effects Oral glucose tolerance test (mg/dL) (at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height SDS(at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Change in height SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height velocity (cm/year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height velocity SDS · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Change in height velocity SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Citrate vs unfractionated heparin

Major bleeding · CRRT

Citrate probably leads to lower major bleeding compared with unfractionated heparin (moderate certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.22 [0.08, 0.62]
7 studies · 535 participants
Moderate

Unfractionated heparin vs low molecular weight heparin

Successful prevention of clotting · CRRT

It is very uncertain whether unfractionated heparin changes successful prevention of clotting compared with low molecular weight heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.95 [0.7, 1.31]
1 study · 54 participants
Very low

Unfractionated heparin vs low molecular weight heparin

Treatment cessation due to adverse events · CRRT

Unfractionated heparin showed no clear difference in treatment cessation due to adverse events compared with low molecular weight heparin (low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.29 [0.02, 3.53]
2 studies · 77 participants
Low

Unfractionated heparin vs low molecular weight heparin

Recovery of kidney function · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs low molecular weight heparin

Thrombocytopenia · CRRT

It is very uncertain whether unfractionated heparin changes thrombocytopenia compared with low molecular weight heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.57 [0.2, 1.63]
2 studies · 124 participants
Very low

Unfractionated heparin vs low molecular weight heparin

Cost to health care services · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Major bleeding · CRRT

It is very uncertain whether unfractionated heparin changes major bleeding compared with no pharmacological anticoagulation (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.5 [0.05, 4.67]
1 study · 10 participants
Very low

Unfractionated heparin vs no pharmacological anticoagulation

Death at 28 days · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Successful prevention of clotting · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Treatment cessation due to adverse events · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Recovery of kidney function · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Citrate vs unfractionated heparin

Death at 28 days · CRRT

Citrate showed no clear difference in death at 28 days compared with unfractionated heparin (moderate certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 1.06 [0.86, 1.3]
5 studies · 462 participants
Moderate

Unfractionated heparin vs no pharmacological anticoagulation

Thrombocytopenia · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Cost to health care services · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found