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Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).
Leflunomide showed no clear difference in infection compared with methotrexate (low certainty).
The intervention may leads to higher serious infections (low certainty).
Pulse cyclophosphamide showed no clear difference in death at final compared with continuous cyclophosphamide (low certainty).
Mohs micrographic surgery showed no clear difference in recurrence at 3 years compared with surgical excision (low certainty).
The review found no eligible studies for this question.
Radiotherapy may leads to higher recurrence at 3 years compared with surgical excision (with or without frozen section margin control) (low certainty).
Radiotherapy probably leads to lower cosmetic outcome (good/excellent) compared with surgical excision (with or without frozen section margin control) (moderate certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
MAL‐PDT may leads to higher recurrence at 3 years compared with surgical excision (low certainty).
MAL‐PDT probably leads to higher cosmetic outcome (excellent/good) compared with surgical excision (moderate certainty).
MAL‐PDT showed no clear difference in pain compared with surgical excision (low certainty).
MAL‐PDT probably leads to higher early treatment failure compared with surgical excision (moderate certainty).
Imiquimod cream probably leads to lower recurrence at 3 years compared with MAL‐PDT (moderate certainty).
Imiquimod cream showed no clear difference in cosmetic outcome (excellent/good) compared with MAL‐PDT (moderate certainty).
Imiquimod cream probably leads to lower pain (moderate/severe) compared with MAL‐PDT (moderate certainty).
Imiquimod cream showed no clear difference in early treatment failure compared with MAL‐PDT (moderate certainty).