Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Regimens containing quinolone vs regimens containing cephalosporin

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

Regimens containing quinolone showed no clear difference in clinical cure according to criteria established by study authors… compared with regimens containing cephalosporins (low certainty).

1 finding from 1 review

Rufinamide vs placebo

50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy

Rufinamide probably leads to higher 50% or greater reduction in seizure frequency ‐ ITT analysis compared with placebo (moderate certainty).

1 finding from 1 review

Rufinamide vs placebo

Frequency of adverse effects ‐ dizziness ( · people with drug‐resistant focal epilepsy

Rufinamide probably leads to higher adverse effects: dizziness compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall BPSD (multidomain) – not assessed · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Agitation · dementia
1 finding from 1 review

Intervention not reported

Depression – assessed in one study as "withdrawn behaviours" which included a lack of interest and sad mood · dementia
1 finding from 1 review

Intervention not reported

Anxiety ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Dropouts ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Final height and change in height · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review