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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,956 questions in 143 reviews · Musculoskeletal
current versionsNo studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and interpositional arthroplasty (T and IA) Trapeziometacarpal joint imaging ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Pain 100mm VAS. Scale from: 1 to 100. · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | 2 studies · 77 participants | Very low |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Physical function ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Quality of life ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Global assessment ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Adverse events Mild to moderate swelling · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | RR 0.09 [0.01, 0.61] | 1 study · 98 participants | Very low |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Treatment failure Reoperation due to pain · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | RR 0.14 [0.01, 2.36] | 1 study · 98 participants | Very low |
Trapeziectomy with interpositional arthroplasty (T and IA) vs Artelon joint resurfacing Trapeziometacarpal joint imaging ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Pain 100mm VAS. Scale from: 0 to 100. · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | 1 study · 26 participants | Low |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy (T) Quality of life ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Physical function ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Quality of life ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Global assessment ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | RR 0.2 [0.01, 3.8] | 1 study · 26 participants | Low |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Treatment failure ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson) Trapeziometacarpal joint imaging ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Pain ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Physical function ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Quality of life ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Global assessment ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy (T) Global assessment ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | RR 1.44 [0.41, 5.05] | 1 study · 99 participants | Moderate |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Treatment failure ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T) Trapeziometacarpal joint imaging ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy (T) Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | RR 1.81 [0.96, 3.73] | 4 studies · 328 participants | Low |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy (T) Treatment failure ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy (T) Trapeziometacarpal joint imaging Scapho‐metacarpal distance · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | 1 study · 42 participants | Low |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and ligament reconstruction (T and LR) Pain ‐ not measured · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | no estimate extracted | NR | No studies |
Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and ligament reconstruction (T and LR) Physical function Buck‐Gramcko score: Number with good‐excellent total score · Patients with thumb (trapeziometacarpal joint) osteoarthritis Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2015) · Cochrane | RR 0.82 [0.63, 1.06] | 1 study · 31 participants | Low |
Intervention NR Pain intensity Various pain scales. (median · participants with osteoarthritis of the knee Intra‐articular corticosteroid for knee osteoarthritis (2015) · Cochrane | no estimate extracted | 26 studies · 1749 participants | Low |
Intervention NR Function Various function scales. (median · participants with osteoarthritis of the knee Intra‐articular corticosteroid for knee osteoarthritis (2015) · Cochrane | no estimate extracted | 15 studies · 1014 participants | Low |
Intervention NR Number of participants experiencing any adverse event (median · participants with osteoarthritis of the knee Intra‐articular corticosteroid for knee osteoarthritis (2015) · Cochrane | RR 0.89 [0.64, 1.23] | 2 studies · 84 participants | Low |
Intervention NR Number of participants who withdraw because of adverse events (median · participants with osteoarthritis of the knee Intra‐articular corticosteroid for knee osteoarthritis (2015) · Cochrane | RR 0.33 [0.05, 2.07] | 2 studies · 204 participants | Low |
Intervention NR Number of participants experiencing any serious adverse event (median · participants with osteoarthritis of the knee Intra‐articular corticosteroid for knee osteoarthritis (2015) · Cochrane | RR 0.63 [0.15, 2.67] | 5 studies · 331 participants | Low |
Intervention NR ASAS40 TNF‐alpha inhibitors for ankylosing spondylitis (2015) · Cochrane | no estimate extracted | 40 participants | Ungraded |
Intervention NR BASFI (0 to 10 scale) TNF‐alpha inhibitors for ankylosing spondylitis (2015) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR ASAS partial remission TNF‐alpha inhibitors for ankylosing spondylitis (2015) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Radiographic progression TNF‐alpha inhibitors for ankylosing spondylitis (2015) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Withdrawals due to adverse events TNF‐alpha inhibitors for ankylosing spondylitis (2015) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Serious adverse events TNF‐alpha inhibitors for ankylosing spondylitis (2015) · Cochrane | no estimate extracted | NR | No studies |
Chondroitin vs placebo Pain on a 0 to 100 mm scale ‐ Short‐term studies (< 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 8 studies · 1077 participants | Low |
Chondroitin with or without glucosamine vs placebo/control Composite Measure of Pain, Function and Disability as assessed through Lequesne's index Scale from 0 to 24 (lower indicates less pain and disability) · participants with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 10 studies · 1756 participants | Low |
Chondroitin with or without glucosamine vs placebo/control Pain (short‐ and long‐term) Scale from 0 to 100 (lower is better) · participants with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 22 studies · 3038 participants | Low |
Chondroitin with or without glucosamine vs placebo/control Physical function (short‐ and long‐term) Scale from 0 to 100 (lower is better) · participants with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 5 studies · 1163 participants | Moderate |
Chondroitin with or without glucosamine vs placebo/control Composite Measure of Pain, Function and Disability as assessed through Lequesne's index (short‐ and long‐term) Scale from 0 to 24 (lower indicates less pain and disability) · participants with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 16 studies · 2334 participants | Moderate |
Chondroitin vs placebo Pain on a 0 to 100 scale ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 6 studies · 989 participants | Low |
Chondroitin vs placebo WOMAC MCII Pain subscale (reduction in knee pain by 20%) ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d · patients with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | RR 1.12 [1.01, 1.24] | 2 studies · 1253 participants | High |
Chondroitin vs placebo Composite Measure of Pain, Function and Disability as · patients with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 7 studies · 903 participants | Moderate |
Chondroitin vs placebo Radiographic Outcome: Reduction in Minimum Joint Space Width (JSW) in mm ‐ Long‐term studies (≥ 6 months)—dose ≥ 800 mg/d Scale: millimeters (smaller decrease in reduction in minimum joint space width is better) · patients with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | no estimate extracted | 2 studies · 922 participants | High |
Chondroitin vs placebo Withdrawals due to adverse events · patients with osteoarthritis Chondroitin for osteoarthritis (2015) · Cochrane | RR 1.08 [0.74, 1.57] | 10 studies · 2406 participants | Moderate |