What do systematic reviews say?

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Transbuccal miniplate combined with intraoral approach vs Intraoral approach alone

Transbuccal miniplate combined with intraoral approach led to lower wound dehiscence compared with intraoral approach alone; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes

  3 months · Angle of mandible only
  RR 0.43 [0.19, 0.98]
  1 study · 138 participants
  GRADE not reported

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Locking plate vs 2 mm non-locking titanium plates

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Agarwal 2011 reported a significant decrease in VAS pain from week 1 to the 3-month follow-up, with no difference between groups at the follow-up visits, but presented no supporting data.
  1 study
  GRADE not reported

Immediate mobilization vs 2 weeks delayed mobilization (IMF)

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Pain (scale 1 to 10) was minor in both groups with no significant differences (Table 4): 6 weeks 1.55 vs 1.20; 3 months 1.00 vs 2.64; 6 months 1.30 vs 2.71 (immediate release vs IMF). 95% confidence interval not…
  1 study
  GRADE not reported

Locking plate vs 2 mm non-locking titanium plates

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Early premature removal of IMF (from hours up to 2 weeks) was reported in 13 of the 90 participants analysed (Collins 2004); participants released their own IMF or reported that "the wires fell off".
  1 study · 90 participants
  GRADE not reported

2 mm titanium plates vs 2.5 mm bioresorbable plates

2 mm titanium plates showed no clear difference in post-operative pain (residual pain, any severity) compared with 2.5 mm bioresorbable plates; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes

  1 month
  RR 1.26 [0.57, 2.82]
  1 study · 40 participants
  GRADE not reported

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) led to higher patients using rescue medication at 8 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg…; GRADE not reported.

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  8 hours postdosing
  RR 2.02 [1.57, 2.60]
  2 studies
  GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  8 hours postdosing · Paracetamol 1000/500 mg/ibuprofen 400/200 mg vs single constituent drugs
  RR 1.60 [1.36, 1.88]
  2 studies · 467 participants
  High

Immediate mobilization vs 2 weeks delayed mobilization (IMF)

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  One wound separation and one infection in the immediate-mobilization group. Inferior alveolar nerve status (scale 1 to 3) showed no significant difference at 6 weeks (P=0.76), 3 months (P=0.87) or 6 months (P=0.99).…
  1 study
  GRADE not reported

Immediate mobilization vs 2 weeks delayed mobilization (IMF)

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  In the IMF (delayed) group, one participant (7.7%) had a wound infection and plate exposure leading to plate removal 4 months post-operatively.
  1 study
  GRADE not reported

Two lag screws vs One lag screw (with arch bars and IMF)

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Drill-bit fracture occurred during preparation in one participant in the two-lag-screws group.
  1 study
  GRADE not reported

Immediate mobilization vs 2 weeks delayed mobilization (IMF)

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Limited data: at the conclusion of the study all participants indicated that they had returned to their "baseline bite".
  1 study
  GRADE not reported

2 mm titanium plates vs 2.5 mm bioresorbable plates

2 mm titanium plates showed no clear difference in segmental mobility compared with 2.5 mm bioresorbable plates; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes

  1 month
  RR 3.84 [0.85, 17.4]
  1 study · 57 participants
  GRADE not reported

Locking plate vs 2 mm non-locking titanium plates

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Functional occlusion was achieved in all participants in both intervention groups (Agarwal 2011); the measurement of this outcome was not clearly reported. Bite force was reported as a surrogate/proxy outcome.
  1 study
  GRADE not reported

One microplate plus one miniplate vs Two miniplates

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  Only one study (Gupta 2012) compared one microplate in conjunction with one miniplate versus two miniplates in isolated interforaminal fractures; however, the data reported in the trial did not satisfy the review's…
  1 study
  GRADE not reported

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  7 studies
  GRADE not reported

Locking plate vs 2 mm non-locking titanium plates

2 mm locking titanium plates showed no clear difference in post-operative infection compared with 2 mm non-locking titanium plates; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
  OR 0.90 [0.1, 7]
  1 study
  GRADE not reported