Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

563 questions · 568 findings · 104 reviews · Headline outcomes only

No studies found 53 · 9.3%GRADE not reported 26 · 4.6%Very low 85 · 15%Low 214 · 37.7%Moderate 151 · 26.6%High 39 · 6.9%

Intervention not reported

Serum/plasma creatinine levels (μmol/L) after treatment Normal values for male and female newborns 17.7 to 88.4 µmol/L · preterm infants with patent ductus arteriosus

The intervention showed no clear difference in serum/plasma creatinine levels (μmol/L) after treatment Normal… (low certainty).

1 finding from 1 review

Intervention not reported

Failure to close a patent ductus arteriosus after 3 doses of ibuprofen · preterm infants with patent ductus arteriosus

The intervention probably leads to lower failure to close a patent ductus arteriosus after 3 doses of ibuprofen (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure to close a patent ductus arteriosus (PDA) (after single or 3 doses) · preterm infants with patent ductus arteriosus

The intervention showed no clear difference in failure to close a patent ductus arteriosus (PDA) (after single or 3… (moderate certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Death of baby (up to discharge) · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping probably leads to lower death of baby (up to discharge) compared with ECC (subgroup analysis by gestation) (moderate certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (low certainty).

1 finding from 1 review