Relapse · adults (age 18 years and older) with EGPA ANCA‐associated vasculitis
Mepolizumab probably leads to lower disease relapse compared with placebo (moderate certainty).
1 finding from 1 review
RR 0.68 [0.53, 0.86]
Studies not reported
Moderate
Disease flare · adults (age 18 years and older) with EGPA ANCA‐associated vasculitis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Any adverse event · adults (age 18 years and older) with EGPA ANCA‐associated vasculitis
Mepolizumab showed no clear difference in any adverse event compared with placebo (low certainty).
1 finding from 1 review
RR 1.03 [0.96, 1.11]
Studies not reported
Low
Any serious adverse event · adults (age 18 years and older) with EGPA ANCA‐associated vasculitis
Mepolizumab showed no clear difference in any serious adverse event compared with placebo (low certainty).
1 finding from 1 review
RR 0.67 [0.35, 1.28]
Studies not reported
Low
Withdrawals due to adverse events · adults (age 18 years and older) with EGPA ANCA‐associated vasculitis
Mepolizumab showed no clear difference in any withdrawals due to AEs compared with placebo (low certainty).
1 finding from 1 review
RR 2 [0.19, 21.54]
Studies not reported
Low
MortalityNumber of participants: 285(2 RCTs) WGET 2005 · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…
Active drug (etanercept or belimumab) with standard therapy showed no clear difference in mortalityNumber of participants: 285(2 RCTs) WGET 2005 compared with standard therapy with placebo (low certainty).
1 finding from 1 review
Incidence of dementia · older people with age‐related memory loss
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Gastrointestinal adverse events · older people with age‐related memory loss
NSAIDs (celecoxib) may leads to higher adverse events – gastrointestinal compared with placebo (low certainty).
1 finding from 1 review
All‐cause mortality · older people with age‐related memory loss
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cognitive decline · older people with age‐related memory loss
1 finding from 1 review
Activities of daily living · older people with age‐related memory loss
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · older people with age‐related memory loss
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Resilience Measured by: investigators measured resilience using different instruments; higher scores mean higher resilience Timing of outcome assessment: post‐intervention · healthcare workers
1 finding from 1 review
Anxiety · healthcare workers
1 finding from 1 review
Depressive symptoms · healthcare workers
1 finding from 1 review
Mental health and well‐being: stress or stress perceptionMeasured by: investigators measured stress or stress perception using different instruments; lower scores mean lower stress or stress perception Timing of outcome assessment: post‐intervention · healthcare workers
1 finding from 1 review
Quality of life/Mental health outcome · healthcare workers
1 finding from 1 review
Adverse events · healthcare workers
1 finding from 1 review
Intervention not reported
Depression score Scales: Beck Depression Inventory, Center for Epidemiologic Studies Short Depression Scale, Patient Health Questionnaire Direction: lower better · women aged 16 years and older who self‐report previous or current experience of intimate partner violence
1 finding from 1 review
Intervention not reported
Self‐efficacy score Scale: Generalized Self‐Efficacy Scale Direction: higher better · women aged 16 years and older who self‐report previous or current experience of intimate partner violence
1 finding from 1 review