Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Sputum culture conversion at 8 weeks · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes sputum culture conversion at 8 weeks compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes serious adverse events compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Relapse · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes relapse compared with standard regimen (very low certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Death before 1 year of age · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in infant death (age < 1 year) compared with control (low certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Bronchopulmonary dysplasia · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in bronchopulmonary dysplasia (at 36 to 38 weeks' PMA) compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

ROP, stage ≥ 3 or ≥ 2 · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in ROP, stage ≥ 3 or ≥ 2 compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Sepsis · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in sepsis (early or late onset) compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Necrotizing enterocolitis (suspected or proven) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in necrotizing enterocolitis (suspected or proven) compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Severe intraventricular haemorrhage · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in intraventricular haemorrhage, grade > 2 compared with control (moderate certainty).

1 finding from 1 review