Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,361 questions · 1,518 findings · 352 reviews

No studies found 73 · 4.8%GRADE not reported 211 · 13.9%Very low 500 · 32.9%Low 411 · 27.1%Moderate 252 · 16.6%High 71 · 4.7%

Intervention not reported

Mobilityd ‐ overall analysis Using different mobility scales: mPPT (range 0 to 36), POMA (range 0 to 30), SPPB (range 0 to 12), PPME (range 0 to 12). A higher score indicates better mobility. · adults following hip fracture surgery

The intervention leads to higher mobilityd ‐ overall analysis Using different mobility scales: mPPT… (high certainty).

1 finding from 1 review

Intervention not reported

Walking speedg ‐ overall analysis Measured using metres/second (m/s) and metres/minute (m/min). A higher score indicates faster walking. · adults following hip fracture surgery

The intervention leads to higher walking speedg ‐ overall analysis Measured using metres/second (m/s)… (high certainty).

1 finding from 1 review

Intervention not reported

Functioningi ‐ overall analysis Using different functioning scales: FSQ (range 0 to 36), BI (range 0 to 100), AM‐PAC daily activity (range 9 to 101), COPM (range 0 to 20), LEFS (range 0 to 80), NEADL (range 0 to 66). A higher score indicates bette... · adults following hip fracture surgery

The intervention leads to higher functioningi ‐ overall analysis Using different functioning scales:… (high certainty).

1 finding from 1 review

Intervention not reported

HRQoL using EQ‐ 5D (range 0 to 1), SF‐36 (range 0 to 100), SF‐12 (range 0 to 100), and WHOQOL‐BREF (range 0 to 130). A higher score indicates better quality of life. · adults following hip fracture surgery

The intervention showed no clear difference in HRQoL using EQ‐ 5D (range 0 to 1), SF‐36 (range 0 to 100), SF‐12… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mobility scales, using different scales: SPPB (range 0 to 12), PPME (range 0 to 12). A higher score indicates better mobility. · adults following hip fracture surgery

The intervention leads to higher mobility scales, using different scales: SPPB (range 0 to 12), PPME… (high certainty).

1 finding from 1 review

Intervention not reported

Walking speedg ‐ overall analysis Measured using metres/second (m/s) and metres/minute (m/min). A higher score indicates faster walking. · adults following hip fracture surgery

The intervention showed no clear difference in walking speedg ‐ overall analysis Measured using metres/second (m/s)… (moderate certainty).

1 finding from 1 review

Intervention not reported

Functioningi ‐ overall analysis Using different scales: mBI (range 0 to 20), BI (range 0 to 100), FIM (range 18 to 126), NEADL (range 0 to 66). A higher score indicates better functioning. · adults following hip fracture surgery

It is very uncertain whether the intervention changes functioningi ‐ overall analysis Using different scales: mBI (range 0… (very low certainty).

1 finding from 1 review

Intervention not reported

HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher score indicates better quality of life. · adults following hip fracture surgery

It is very uncertain whether the intervention changes HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher… (very low certainty).

1 finding from 1 review

Intervention not reported

Mobility scales, using different mobility scales: MILA (range 0 to 36), EMS (range 0 to 20), BBS (range 0 to 56), PPME (range 0 to 12), Koval (range 1 to 7). Higher values indicate better mobility (except MILA and Koval, where scale was inverted f... · adults following hip fracture surgery

The intervention probably leads to higher mobility scales, using different mobility scales: MILA (range 0 to… (moderate certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple: dosage and timing of… compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

Adverse events (grade ≥ 3) · newly‐diagnosed EOC

It is very uncertain whether summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy changes any severe adverse event (grade 3 or higher) (G3+ SevAE ) compared with placebo (maintenance therapy) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi monotherapy vs chemotherapy alone

Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi… showed no clear difference in any severe adverse event (grade 3 or higher) (G3+ SevAE) compared with chemotherapy (low certainty).

1 finding from 1 review

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi monotherapy vs placebo (maintenance therapy)

Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi… may leads to higher any severe adverse event (grade 3 or higher) (G3+ SevAE) compared with placebo after chemotherapy (maintenance therapy) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi with chemotherapy vs chemotherapy alone

Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi… showed no clear difference in any severe adverse event (grade 3 or higher) (G3+ SevAE) compared with chemotherapy alone (low certainty).

1 finding from 1 review