Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

HALOPERIDOL vs placebo

The event rate of intensive care delirium within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Day care programs combined with playpen provision vs playpen provision

Drowning mortality rate · 9‐ to 47‐month‐old children in LMICs

It is very uncertain whether day care programs combined with playpen provision changes drowning mortality rate compared with playpen provision (very low certainty).

1 finding from 1 review

Voiding education with uroflowmetry and feedback vs anticholinergics

Resolution of daytime urinary incontinence · children aged 6 to 12 years with overactive bladder with urge incontinence

It is very uncertain whether voiding education with uroflowmetry and feedback changes resolution of daytime urinary incontinence at 12 months after 6… compared with anticholinergics (very low certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Clinician‐rated global impression test (improved compared with baseline assessed using CIBIC‐plus at 24 weeks) · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher clinician‐rated global impression tests (improved compared with… compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Secondary outcome: acceptability of treatment · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Risk for at least one adverse event per patient · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with placebo (moderate certainty).

1 finding from 1 review