What do systematic reviews say?

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

Reduction in target/mean lesion size · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
No statistical testing of the mean surface area of lesions was reported in Hegarty 2002 (fluticasone mean score 547.2 mm2 versus betamethasone mean score 671.9 mm2).
1 study · 22 participants
GRADE not reported

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
4 months (18 weeks)
No recurrence of peri-implantitis occurred in any of the groups.
1 study · 28 participants
GRADE not reported

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Restoration of sexual activity · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
None of the included studies assessed the effectiveness of treatments of genital ELP; thus, this outcome was not reported.
0 studies
No studies found

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser showed no clear difference in change in probing pocket depth compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
6 months
After 6 months no statistically significant difference between Er:YAG laser and air-abrasive device for PPD.
1 study · 42 participants
GRADE not reported

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel)

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months
No adverse events were associated with receiving vitamin B12 or placebo in this study.
1 study · 58 participants
GRADE not reported

Topical corticosteroids vs Another topical agent or placebo

Healing of ulceration · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
0 studies
No studies found

1% pimecrolimus cream vs Placebo (vehicle cream)

Clinical response ‐ complete response · People with erosive oral lichen planus

1% pimecrolimus cream showed no clear difference in complete clinical response (complete clearance) compared with placebo (vehicle cream); GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 3.50 [0.95, 12.90]
1 study · 20 participants
GRADE not reported

LongoVital (herbal component alone) vs placebo

General degree of discomfort · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

LongoVital (herbal component alone) showed no clear difference in general degree of discomfort compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
4 to 6 months
MD -0.30 [-0.37, 0.97]
1 study · 50 participants
GRADE not reported

Sodium hypochlorite 5.25% vs Normal saline

The review found no eligible studies for this question.

1 finding from 1 review

Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Sulodexide (heparin plus dermatan sulphate chains) vs prednisone

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
Sulodexide was without significant adverse events; one significant adverse event (gastritis) was reported for the prednisone group.
1 study · 20 participants
GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Partial response (partial or complete response) · People with erosive oral lichen planus

Topical ciclosporin 1.5% gel led to higher partial response (partial or complete response) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 1.46 [1.04, 2.04]
1 study · 40 participants
GRADE not reported

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Implant failure · People with at least one dental implant affected by perimplantitis

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
6 months
After 6 months there were no drop-outs, implant failures or complications.
1 study · 42 participants
GRADE not reported

Bee propolis (one 500 mg capsule per day) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 months (minimum)
Propolis was associated with low rates of minimal side effects.
1 study · 19 participants
GRADE not reported

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Mean pain score and mean ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 days
A statistically significant difference was reported in mean pain score and mean ulcer size favouring the homeopathic group (P<0.05). Summary data not presented, precluding further analysis.
1 study · 100 participants
GRADE not reported

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
90 days
No differences in adverse events were reported.
1 study · 50 participants
GRADE not reported

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 days
No participant needed to discontinue treatment due to adverse events.
1 study · 100 participants
GRADE not reported

Flapless implant placement vs Conventional flap elevation

Marginal bone level change · People with dental implants

Flapless implant placement showed no clear difference in peri-implant marginal bone level change compared with conventional flap elevation; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: management of soft tissues for dental implants 2012 · Cochrane All outcomes
MD -0.05 [-0.25, 0.15]
1 study · 78 participants
GRADE not reported

Er:YAG laser surface debridement before bone augmentation vs Plastic curettes plus saline solution before bone augmentation

Complications and side effects · People with at least one dental implant affected by perimplantitis

Er:YAG laser surface debridement before bone augmentation led to lower complications and side effects compared with plastic curettes plus saline solution before bone augmentation; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
6 months
All patients experienced flap exposure during healing, not associated with infective complications; one patient had a slight pigmentation of the peri-implant soft tissues.
1 study · 30 participants
GRADE not reported