Findings

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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Brief motivational interviewing (BMI) vs usual treatment alone

Alcohol consumption: consuming more than 21 units of alcohol per week · Male patients aged 16 to 35 years attending an oral and maxillofacial surgery outpatient clinic for follow-up of an alcohol-related facial…

Brief one-session, manual-guided discussion based on the principles… led to lower alcohol consumption: consuming more than 21 units of alcohol per week compared with treatment at the outpatient clinic as usual; GRADE not reported.

1 finding from 1 review

Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme

Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

Sodium hypochlorite 5% showed no clear difference in proportion of participants with new or worsening signs/symptoms of… compared with sodium hypochlorite 5% with proteolytic enzyme; GRADE not reported.

1 finding from 1 review

Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Total number of new ulcers over 90 days · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) led to lower total number of new ulcers over 90 days compared with placebo; GRADE not reported.

1 finding from 1 review

Sodium hypochlorite 5.25% vs Normal saline

Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Dietary counselling tailored to a Stage of Change (Transtheoretical Model) to increase fruit and vegetable intake (two counselling sessions) vs usual care

Body‐mass index (BMI) · Edentulous patients aged 45 to 80 years attending dental-student teaching clinics for replacement dentures, Newcastle Dental Hospital, UK
1 finding from 1 review

Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
1 finding from 1 review

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing attachment level (PAL) · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement showed no clear difference in change in probing attachment level (PAL) compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Any topical or systemic intervention vs Placebo, no treatment, or another intervention

Outcome not reported · People with erosive anogenital (genital) lichen planus

The review found no eligible studies for this question.

1 finding from 1 review

RDP with I-bar clasps / mesial rests vs RDP with circumferential clasps / distal rests

Change in abutment tooth mobility at 60 months · Partially edentulous patients treated with a removable dental prosthesis (RDP)

RDP with I-bar clasps / mesial rests showed no clear difference in change in abutment tooth mobility at 60 months compared with RDP with circumferential clasps / distal rests; GRADE not reported.

1 finding from 1 review

Vertical ramus osteotomy (VRO) with osteosynthesis vs Vertical ramus osteotomy (VRO) without osteosynthesis

Changes in condyle position: fossa-condyle relations for anterior (1 year post-operative) · Adults (16 years of age or older) with an Angle Class III malocclusion (prominent lower front teeth); people with syndromes, clefts or…

Vertical ramus osteotomy (VRO) with osteosynthesis showed no clear difference in changes in condyle position: fossa-condyle relations for anterior (1… compared with vertical ramus osteotomy (VRO) without osteosynthesis; GRADE not reported.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Presence of TMJ sounds · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate led to lower presence of TMJ sounds compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review

Topical thalidomide vs Another topical agent or placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical corticosteroids vs Another topical agent or placebo

Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found