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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Bee propolis (one 500 mg capsule per day) vs placebo

Quality of life · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Extraction of the primary maxillary canine vs no intervention

Patient satisfaction and pain experience during extraction of the primary canine · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…

The review found no eligible studies for this question.

1 finding from 1 review

Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

Topical ciclosporin 1.5% gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Effectiveness · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in gingival recession (REC) · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement showed no clear difference in change in gingival recession (REC) compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Mean VAS pain per day · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in mean VAS pain per day compared with placebo; GRADE not reported.

1 finding from 1 review

Sodium hypochlorite 5.25% vs Normal saline

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

Sodium hypochlorite 5.25% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with normal saline; GRADE not reported.

1 finding from 1 review

Denzir all-ceramic FDP vs In-Ceram Zirconia all-ceramic FDP

Reconstruction failure / chip fractures (12 months) · Patients with all-ceramic implant FDP reconstructions; parallel group, 12-month
1 finding from 1 review

Sodium hypochlorite 1% with chlorhexidine 2% final rinse vs Sodium hypochlorite 1% with normal saline final rinse

Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Sulodexide (heparin plus dermatan sulphate chains) vs placebo

Days to resolution of pain / epithelialization; number of aphthae per month · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

Average duration of RAS episode (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to lower average duration of RAS episode (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Subepithelial connective tissue graft (palate) at implant placement vs No augmentation

Aesthetic preference evaluated by the patient (split-mouth design studies) · Partially edentulous patients receiving posterior mandibular implants

Subepithelial connective tissue graft (palate) at implant placement led to lower patient preference (aesthetics evaluated by patients) compared with no augmentation; GRADE not reported.

1 finding from 1 review

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs Montelukast (leukotriene receptor antagonist)

Time to resolution of first ulcer (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Prednisone (oral, commencing 25 mg with phased dose reduction over 2… led to lower time to resolution of first ulcer (days) compared with montelukast (leukotriene receptor antagonist); GRADE not reported.

1 finding from 1 review

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review