Intervention not reported
Time from administration of OWSC to resolution of MBO. · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Survival time from onset of inoperable MBO until death. · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Dental caries · Children or adults (fit and healthy, or with a well-defined medical condition)
The review found no eligible studies for this question.
1 finding from 1 review
Dental caries · Children or adults (fit and healthy, or with a well-defined medical condition)
1 finding from 1 review
Plaque · Children or adults (fit and healthy, or with a well-defined medical condition)
It is very uncertain whether enhanced one-to-one OHA changes periodontal health: plaque levels compared with one-to-one OHA (standard) (very low certainty).
1 finding from 1 review
SoF: 2 studies did not report usable data; 1 study gave low-quality evidence of a benefit in plaque reduction at 5.5 months for enhanced OHA; 3 studies found little or no difference; 1 study gave weak evidence of a…
6 studies · 440 participants
Very low
Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition)
1 finding from 1 review
Hoogstraten 1983 (dental knowledge, attitude, behaviour, fear), Munster Halvari 2012 (multiple psychological measures: autonomy, motivation, perceived competence), Tedesco 1992 (theory of reasoned action variables);…
3 studies
GRADE not reported
Cost‐effectiveness · Children or adults (fit and healthy, or with a well-defined medical condition)
1 finding from 1 review
Plaque · Children or adults (fit and healthy, or with a well-defined medical condition)
It is very uncertain whether personalised one-to-one OHA changes periodontal health: plaque levels compared with routine one-to-one OHA (very low certainty).
1 finding from 1 review
SoF: 1 study showed a benefit for personalised OHA at 3 and 12 months; 1 study in children reported 'statistically significant (P < 0.05) improvement' but no usable data; 1 study showed little or no difference at 3…
3 studies · 308 participants
Very low
Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition)
1 finding from 1 review
Plaque · Children or adults (fit and healthy, or with a well-defined medical condition)
It is very uncertain whether self-management (self-administered/self-monitored OHA) changes periodontal health: plaque levels compared with professional OHA (very low certainty).
1 finding from 1 review
SoF: 2 studies reported no significant differences but no usable data; 1 study gave weak evidence of a benefit in plaque reduction at 3 months for self-management; 1 study in adults with hyposalivation gave very weak…
4 studies · 181 participants
Very low
Normalcy of diet (mean worst ability to eat, 1 to 4 scale) · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (mean worst ability to eat, 1 to 4 scale) compared with placebo; GRADE not reported.
1 finding from 1 review
Interruptions to cancer treatment (radiotherapy interruptions) · Adults with cancer receiving treatment
Granulocyte-colony stimulating factor (G-CSF) showed no clear difference in interruptions to cancer treatment (radiotherapy interruptions) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Interruptions to cancer treatment · Adults receiving radiotherapy to the head and neck
Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in interruptions to cancer treatment compared with sucralfate mouthwash; GRADE not reported.
1 finding from 1 review
Adverse events · Adults with cancer receiving treatment
1 finding from 1 review
Adverse events attributed to GM-CSF typically bone pain, nausea, fever and headache; not reported as serious; reporting poor and inconsistent (SoF comments cell, not GRADE-rated)
8 studies
GRADE not reported
Number of days in hospital · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days in hospital compared with placebo; GRADE not reported.
1 finding from 1 review
Adverse events · Adults with cancer receiving treatment
1 finding from 1 review
Adverse events attributed to KGF were typically oral-related or skin-related; mostly mild to moderate with very few serious events; reporting poor and inconsistent, not appropriate to meta-analyse (SoF comments cell,…
16 studies
GRADE not reported
Normalcy of diet (total parenteral nutrition) · Children receiving bone marrow/stem cell transplantation after conditioning therapy for mixed cancers
Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple…; GRADE not reported.
1 finding from 1 review
Quality of life · Adults with cancer receiving treatment
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with cancer receiving treatment
1 finding from 1 review
Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults receiving radiotherapy to the head and neck
Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with sucralfate mouthwash; GRADE not reported.
1 finding from 1 review