Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

563 questions · 568 findings · 104 reviews · Headline outcomes only

No studies found 53 · 9.3%GRADE not reported 26 · 4.6%Very low 85 · 15%Low 214 · 37.7%Moderate 151 · 26.6%High 39 · 6.9%

Slow vs faster rates of enteral feed advancement

Necrotising enterocolitis · very preterm or very low birth weight infants

Slow showed no clear difference in necrotising enterocolitis before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow vs faster rates of enteral feed advancement

Mortality before hospital discharge · very preterm or very low birth weight infants

Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow vs faster rates of enteral feed advancement

Invasive infection (before hospital discharge) · very preterm or very low birth weight infants

Slow showed no clear difference in invasive infection before hospital discharge compared with faster rates of enteral feed advancement (low certainty).

1 finding from 1 review

Intervention not reported

Perinatal mortality · women undergoing home monitoring for preventing preterm birth versus women receiving standard care

The intervention showed no clear difference in perinatal mortality (low certainty).

1 finding from 1 review

Intervention not reported

Antenatal hospital admissions · women undergoing home monitoring for preventing preterm birth versus women receiving standard care

The intervention showed no clear difference in antenatal hospital admissions (low certainty).

1 finding from 1 review

Intervention not reported

Admission to NICU · women undergoing home monitoring for preventing preterm birth versus women receiving standard care

The intervention probably leads to lower admission to NICU (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of unscheduled antenatal visits · women undergoing home monitoring for preventing preterm birth versus women receiving standard care
1 finding from 1 review

Intervention not reported

Use of tocolysis · women undergoing home monitoring for preventing preterm birth versus women receiving standard care

The intervention may leads to higher use of tocolysis (low certainty).

1 finding from 1 review

Paracetamol vs indomethacin

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with indomethacin (low certainty).

1 finding from 1 review

Prophylactic administration of paracetamol vs placebo or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA

Prophylactic administration of paracetamol may leads to lower failure of PDA closure after first course (assessed by… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Prophylactic administration of paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm infants with PDA

Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).

1 finding from 1 review