Intervention not reported
Severity of depression dichotomous measures ‐ Tricyclics versus placebo: "very much" or "much" improvement on the Clinical Global Impression scale · patients with depression during opioid agonist treatment for opioid dependence
The intervention probably leads to higher severity of depression dichotomous measures ‐ Tricyclics versus… (moderate certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ Withdrawn for medical reasons: Tricyclics versus placebo · patients with depression during opioid agonist treatment for opioid dependence
The intervention leads to higher adverse events ‐ Withdrawn for medical reasons: Tricyclics versus… (high certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ Withdrawn for medical reasons: SSRI versus placebo · patients with depression during opioid agonist treatment for opioid dependence
The intervention showed no clear difference in adverse events ‐ Withdrawn for medical reasons: SSRI versus placebo (high certainty).
1 finding from 1 review
Dropout ‐ Studies with low risk of bias · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants showed no clear difference in dropout ‐ Studies with low risk of bias compared with placebo according to any definition (high certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo according to any definition (low certainty).
1 finding from 1 review
Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo according to any definition (low certainty).
1 finding from 1 review
Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).
1 finding from 1 review
Dropout · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants showed no clear difference in dropout compared with placebo (moderate certainty).
1 finding from 1 review
Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo (low certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo (low certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Bupropion leads to higher smoking cessation (at least six months of compared with placebo/no pharmacological treatment (high certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion showed no clear difference in serious adverse events compared with placebo/no pharmacological treatment (moderate certainty).
1 finding from 1 review
NFCS pain score during the procedure№ of infants: 112(2 RCTs) Score · procedural pain in neonates
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Pain score assessed up to 10 minutes after the procedure · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Episodes of bradycardia · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Episodes of apnea · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypotension requiring medical therapy (vasopressors or fluid boluses), occurring during the procedure · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
ADHD symptom severity: clinician rated · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
1 finding from 1 review
ADHD symptoms: self‐reported Assessed by: various scales · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
1 finding from 1 review
Symptoms of depression · depression in adults
1 finding from 1 review