(621) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
2 findings from 1 review
(5032) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(1003) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(242) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(2693) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(2601) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(4984) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(513) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(939) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
(2384) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…
1 finding from 1 review
Post-treatment pain within 1 week (from first session) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment probably leads to higher post-treatment pain within 1 week (from first session) compared with multiple-visit root canal treatment (two or more visits) (moderate certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment showed no clear difference in postoperative pain in the immediate postobturation period (up to 72… compared with multiple-visit root canal treatment (two or more visits) (low certainty).
1 finding from 1 review
Tooth extraction due to endodontic problems · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
It is very uncertain whether single-visit root canal treatment changes tooth extraction due to endodontic problems compared with multiple-visit root canal treatment (two or more visits) (very low certainty).
1 finding from 1 review
Swelling or flare-up · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
It is very uncertain whether single-visit root canal treatment changes swelling or flare-up compared with multiple-visit root canal treatment (two or more visits) (very low certainty).
1 finding from 1 review
Analgesic (painkiller) use · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
It is very uncertain whether single-visit root canal treatment changes analgesic (painkiller) use compared with multiple-visit root canal treatment (two or more visits) (very low certainty).
1 finding from 1 review
Pain at two weeks (postobturation) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment showed no clear difference in pain at two weeks (postobturation) compared with multiple-visit root canal treatment (two or more visits); GRADE not reported.
1 finding from 1 review
Relapse · patients with relapsing‐remitting multiple sclerosis
Ocrelizumab probably leads to lower number of participants experiencing ≥ 1 relapse compared with interferon beta‐1a (moderate certainty).
1 finding from 1 review
Number of participants with any serious adverse events · primary progressive multiple sclerosis
Ocrelizumab showed no clear difference in number of participants with any serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Number of adverse events requiring discontinuation of treatment ‐ not reported · primary progressive multiple sclerosis
Ocrelizumab showed no clear difference in number of participants experiencing treatment discontinuation caused… compared with placebo (low certainty).
1 finding from 1 review
Number of participants with gadolinium‐enhancing T1 lesions on MRI · primary progressive multiple sclerosis
The review found no eligible studies for this question.
1 finding from 1 review