Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,266 questions · 1,314 findings · 160 reviews · Headline outcomes only

No studies found 309 · 23.5%GRADE not reported 34 · 2.6%Very low 356 · 27.1%Low 393 · 29.9%Moderate 187 · 14.2%High 35 · 2.7%

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Acute hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes acute hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Transjugular intrahepatic portosystemic shunts vs endoscopic intervention with or without medical treatment

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether transjugular intrahepatic portosystemic shunt changes chronic hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Mortality due to rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes mortality due to rebleeding compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Acute hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes acute hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes chronic hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

5‐ASA vs placebo

Relapse, drop‐outs classed as relapse, grouped by length of · patients with maintenance of medically‐induced remission in Crohn's disease

5‐ASA showed no clear difference in relapse, drop‐outs classed as relapse, grouped by length of compared with placebo (moderate certainty).

3 findings from 1 review

Laparoscopic fundoplication vs medical management

Serious adverse events · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes serious adverse events compared with medical management (very low certainty).

1 finding from 1 review