Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Gestrinone vs leuprolin

Percentage days bleeding or spotting (questionnaire) · women with symptomatic endometriosis

Gestrinone may leads to higher spotting or bleeding compared with leuprolin (low certainty).

1 finding from 1 review

Gestrinone vs danazol

Pelvic pain · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes pelvic pain: none or mild compared with danazol (very low certainty).

1 finding from 1 review

Gestrinone vs danazol

Dysmenorrhoea: none or mild · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes dysmenorrhoea: none or mild compared with danazol (very low certainty).

1 finding from 1 review

Gestrinone vs danazol

Dyspareunia: none or mild · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes dyspareunia: none or mild compared with danazol (very low certainty).

1 finding from 1 review

Gestrinone vs danazol

Side effects ‐ hirsutism · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes side effects: hirsutism compared with danazol (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Death from any cause · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in death from any cause compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

TB‐related death · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in TB‐related death compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Sputum culture conversion at 8 weeks · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in sputum culture conversion at 8 weeks compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in serious adverse events compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Death from any cause · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes death from any cause compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

TB‐related death · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes TB‐related death compared with standard regimen (very low certainty).

1 finding from 1 review