Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Intervention not reported

30‐Day amputation‐free survival · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review

Intervention not reported

30‐Day mortality · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review

Intervention not reported

Presence of PDA on third to fourth day of life (after 72 hours of treatment) · preterm or low birth weight infants with risk of having PDA on day 3 to 4 of life

The intervention probably leads to lower presence of PDA on third to fourth day of life (after 72 hours of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of AAD: Probiotic dose (≥5 billion CFUs of probiotics/day) · Children receiving antibiotic treatment between 4 and 28 days duration for a variety of infections

The intervention probably leads to lower incidence of AAD: Probiotic dose (≥5 billion CFUs of probiotics/day) (moderate certainty).

1 finding from 1 review

Effects of clinically‐indicated replacement vs routine change of peripheral intravenous catheters

Thrombophlebitis (per device days) (during hospitalisation) · any patient requiring a PIVC expected to remain in‐situ for at least 3 days

Effects of clinically‐indicated replacement showed no clear difference in thrombophlebitis (per device days) (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).

1 finding from 1 review

Perioperative alcohol cessation intervention vs treatment

In‐hospital and 30‐day mortality · adult surgical patients consuming 3 or more units of alcohol per day

Perioperative alcohol cessation intervention showed no clear difference in in‐hospital and 30‐day mortality compared with treatment (low certainty).

1 finding from 1 review

Other prokinetics vs domperidone

Not symptom‐free or no symptom improvement · patients with functional dyspepsia

It is very uncertain whether other prokinetics changes not symptom‐free or no symptoms improvement (itopride 50 three times… compared with domperidone 10mg three times a day (very low certainty).

1 finding from 1 review