Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,447 questions · 2,590 findings · 266 reviews

No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Placebo (sham irradiation, laser inactive) vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs Caries-free status

CA VI concentration · Individuals assessed for dental caries (mainly children aged 2-9 years; one study in adults aged 18-24 years)

Salivary CA VI concentration is significantly lower in individuals with dental caries than in caries-free individuals (SMD -0.672, 95% CI -1.011 to -0.332; not GRADE-rated).

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs Caries-free status

CA VI activity · Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years), qualitative only…

Salivary/biofilm CA VI activity is significantly higher in individuals with dental caries than in caries-free individuals (SMD 0.894, 95% CI 0.386 to 1.392; not GRADE-rated).

1 finding from 1 review

Active education + Support for implementation vs Routine care or Passive dissemination

Process outcome, Practitioner Impact 1. Polypharmacy at · patients with schizophrenia or related psychoses

It is very uncertain whether active education + Support for implementation changes process outcome, Practitioner Impact 1. Polypharmacy at compared with routine care or Passive dissemination (very low certainty).

1 finding from 1 review

Active education + Support for implementation vs Routine care or Passive dissemination

Process outcome, Practitioner Impact: 2. Not screened for cardiovascular risk, Framingham score (corrected for design effect) · patients with schizophrenia or related psychoses

It is very uncertain whether active education + Support for implementation changes process outcome, Practitioner Impact: 2. Not screened for… compared with routine care or Passive dissemination (very low certainty).

1 finding from 1 review

Active education + Support for implementation vs Routine care or Passive dissemination

Patient outcome: treatment adherence: not adherent at · patients with schizophrenia or related psychoses

It is very uncertain whether active education + Support for implementation changes patient outcome: treatment adherence: not adherent at compared with routine care or Passive dissemination (very low certainty).

1 finding from 1 review