What do systematic reviews say?

First‐line thiazides vs alpha‐blocker

First‐line thiazides showed no clear difference in total mortality Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.88, 1.09]
  1 study · 24316 participants
  Moderate

First‐line thiazides vs alpha‐blocker

The review found no eligible studies for this question.

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

First‐line thiazides vs alpha‐blocker

First‐line thiazides probably leads to lower total cardiovascular events Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.74 [0.69, 0.8]
  2 studies · 24396 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides showed no clear difference in total stroke Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.86 [0.73, 1.01]
  2 studies · 24396 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides showed no clear difference in total CHD Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.86, 1.11]
  2 studies · 24396 participants
  Low

First‐line thiazides vs alpha‐blocker

First‐line thiazides probably leads to lower total congestive heart failure Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.51 [0.45, 0.58]
  1 study · 24316 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.7 [0.54, 0.89]
  3 studies · 24772 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 18135 participants
  Moderate

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 18135 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 18135 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 6569 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 18501 participants
  Moderate

First‐line thiazides vs calcium channel blockers

First‐line thiazides showed no clear difference in total mortality Duration: 1 to 5 years compared with first‐line calcium channel blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 1.02 [0.96, 1.08]
  7 studies · 35417 participants
  Moderate

First‐line thiazides vs calcium channel blockers

First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 1.09 [0.97, 1.24]
  2 studies · 7204 participants
  Low

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (high certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 765 participants
  High

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (moderate certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 3117 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (moderate certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  35 studies · 4869 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (high certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 881 participants
  High

Intervention not reported

The review found no eligible studies for this question.

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

It is very uncertain whether the intervention changes WDAEs (very low certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  RR 0.81 [0.63, 1.03]
  33 studies · 6187 participants
  Very low