Findings

What do systematic reviews say?

24 questions · 24 findings · 7 reviews · Drugs and Alcohol

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No studies found 3 · 12.5%GRADE not reported 3 · 12.5%Very low 8 · 33.3%Low 4 · 16.7%Moderate 6 · 25%High 0 · 0%

Summary of findings table – disulfiram vs naltrexone

Amount of cocaine use (mean weight of cocaine used or money spent on cocaine at the end of treatment) · patients with the treatment of cocaine dependence

1 finding from 1 review

Disulfiram for the treatment of cocaine dependence 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Low

Baclofen vs naltrexone

Relapse: return to any drinking at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen for alcohol use disorder 2023 · Cochrane Headline outcomes only
RR 2.5 [1.12, 5.56]
1 study · 60 participants
Very low

Baclofen vs naltrexone

Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with ≥ 1 adverse event at end… compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen for alcohol use disorder 2023 · Cochrane Headline outcomes only
RR 0.35 [0.15, 0.8]
2 studies · 80 participants
Very low

Baclofen vs naltrexone

Dropout · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts at end of treatment compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen for alcohol use disorder 2023 · Cochrane Headline outcomes only
RR 1 [0.32, 3.1]
1 study · 60 participants
Very low