Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

538 questions · 561 findings · 59 reviews

No studies found 184 · 32.8%GRADE not reported 185 · 33%Very low 86 · 15.3%Low 58 · 10.3%Moderate 38 · 6.8%High 10 · 1.8%

Age 8-10 years vs Extraction at patient age >10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at age 8-10 (vs after 10) increases odds of space closure (OR 3.32; low certainty).

1 finding from 1 review

Extraction at patient age 11-12 years vs Extraction at patient age 8-10 years

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at 11-12 vs 8-10 years showed no significant difference in one analysis (OR 0.82; not GRADE-rated).

2 findings from 1 review

Extraction of the primary maxillary canine vs no intervention

Patient satisfaction and pain experience during extraction of the primary canine · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…

The review found no eligible studies for this question.

1 finding from 1 review

Second molar distally inclined at extraction vs Second molar upright at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, distal inclination of the second molar vs upright was not significantly associated with space closure (OR 1.18; not GRADE-rated).

1 finding from 1 review

Second molar mesially inclined at extraction vs Second molar upright at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, mesial inclination of the second molar vs upright was not significantly associated with space closure (OR 0.68; not GRADE-rated).

1 finding from 1 review

Extraction of a maxillary first permanent molar vs Extraction of a mandibular permanent first molar

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

Spontaneous space closure is much more likely in the maxilla than the mandible (OR 7.77; low certainty).

1 finding from 1 review

Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar)

In the maxilla, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 4.78; low certainty).

1 finding from 1 review

Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 3.81; low certainty).

1 finding from 1 review

M2 Demirjian stages F-G vs Second molar at Demirjian stage D-E at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage F-G vs D-E was not significantly associated with space closure (OR 0.68; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage A-D at extraction vs Second molar at Demirjian stage G-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage A-D vs G-H was not significantly associated with space closure (OR 2.75; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage E-F at extraction vs Second molar at Demirjian stage G-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, Demirjian stage E-F vs G-H was not significantly associated with space closure (OR 4.44; not GRADE-rated).

1 finding from 1 review

Second molar at Demirjian stage A-D at extraction vs Second molar at Demirjian stage F-H at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, earlier Demirjian stage A-D (vs F-H) increases odds of space closure (OR 3.11; low certainty).

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Immediate-delayed implants (placed within 8 weeks after tooth extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed just after tooth extraction) showed no clear difference in aesthetics assessed by dentist: position of the perimplant tissues compared with immediate-delayed implants (placed within 8 weeks after tooth…; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Immediate-delayed implants (placed within 8 weeks after tooth extraction)

Marginal bone level change · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed just after tooth extraction) showed no clear difference in perimplant marginal bone level changes compared with immediate-delayed implants (placed within 8 weeks after tooth…; GRADE not reported.

1 finding from 1 review

Second molar at Nolla developmental stage 6-7 at extraction vs Second molar at later Nolla stages at extraction

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found mandibular Nolla stage 6-7 associated with better space closure (OR 55.1; single study; not GRADE-rated).

1 finding from 1 review

Unilateral extraction of the mandibular first permanent molar vs Bilateral extraction of the mandibular first permanent molars

Midline deviation of the mandibular arch · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found midline deviation more likely after unilateral than bilateral extraction (OR 11.6; single study; not GRADE-rated).

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Major complications at the implant site · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to higher major complications at the implant site compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: interproximal papilla dimension · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower aesthetics assessed by dentist: interproximal papilla dimension compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower implant failure compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to higher aesthetics assessed by dentist: position of the perimplant tissues compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review