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Evidence found and GRADE certainty

27 questions · 27 findings · 4 reviews · Epilepsy

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No studies found 3 · 11.1%GRADE not reported 0 · 0%Very low 6 · 22.2%Low 4 · 14.8%Moderate 7 · 25.9%High 7 · 25.9%

Topiramate vs carbamazepine

Time to 12‐month remission ‐ all participants Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate leads to lower time to 12‐month remission of seizures All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate leads to lower time to 12‐month remission of seizures Subgroup: focal onset… compared with carbamazepine (high certainty).

1 finding from 1 review

Topiramate vs carbamazepine

Time to 12‐month remission of seizures Subgroup: generalised onset tonic‐clonic seizures or unclassified epilepsy Range of · adults and children with newly onset partial or generalised epilepsy

Topiramate showed no clear difference in time to 12‐month remission of seizures Subgroup: generalised onset… compared with carbamazepine (moderate certainty).

1 finding from 1 review