Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 33 findings · 2 reviews · Common Mental Disorders

No studies found 19 · 57.6%GRADE not reported 0 · 0%Very low 3 · 9.1%Low 6 · 18.2%Moderate 1 · 3%High 4 · 12.1%

Topiramate as add‐on therapy vs alternative drug

Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Lithium vs topiramate

Efficacy: response (categorical) YMRS change ≥ 50% from baseline to end of study · acute mania

Lithium leads to higher efficacy: response (categorical) YMRS change ≥ 50% from baseline to… compared with topiramate (high certainty).

1 finding from 1 review

Lithium vs topiramate

Efficacy: response (continuous) YMRS change by ≥ 50% at end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs topiramate

Remission · acute mania

Lithium leads to higher efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with topiramate (high certainty).

1 finding from 1 review

Lithium vs topiramate

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with topiramate (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.28 [0.66, 2.48]
    2 studies · 1352 participants
    High