Findings

What do systematic reviews say?

23 questions · 23 findings · 4 reviews · Headline outcomes only

No studies found 2 · 8.7%GRADE not reported 0 · 0%Very low 1 · 4.3%Low 10 · 43.5%Moderate 9 · 39.1%High 1 · 4.3%

Pain · preterm infants

1 finding from 1 review

Topical anaesthesia for needle‐related pain in newborn infants 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 110 participants
Low

Successful cannulation at the first attempt · preterm infants

It is very uncertain whether amethocaine changes successful cannulation first attempt compared with placebo (very low certainty).

1 finding from 1 review

Topical anaesthesia for needle‐related pain in newborn infants 2017 · Cochrane Headline outcomes only
RR 1.21 [0.82, 1.81]
1 study · 39 participants
Very low

Adverse effects (short‐lasting skin reactions) · preterm infants

1 finding from 1 review

Topical anaesthesia for needle‐related pain in newborn infants 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 181 participants
Moderate