What do systematic reviews say?

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in plasma level of IL-6 (pg/mL) compared with no treatment (no periodontal treatment); GRADE not reported.

• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Short term · People diagnosed with periodontitis
  MD -0.34 [-1.06, 0.38]
  1 study · 169 participants
  GRADE not reported
• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Long term · People diagnosed with periodontitis
  MD -1.60 [-2.31, -0.89]
  1 study · 168 participants
  GRADE not reported
• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Long term · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
  MD -0.90 [-2.97, 1.17]
  1 study · 48 participants
  GRADE not reported

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Periodontal treatment (subgingival SRP with or without other… led to lower bleeding on probing (BOP) compared with no treatment (no periodontal treatment); GRADE not reported.

• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Long term · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
  MD -36.80 [-46.47, -27.13]
  1 study · 48 participants
  GRADE not reported

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in heart rate compared with no treatment (no periodontal treatment); GRADE not reported.

• Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes

  Long term · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
  MD -0.70 [-6.06, 4.66]
  1 study · 48 participants
  GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Periodontal treatment (scaling and root planing, alone or with… led to lower clinical attachment level compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  MD -0.13 [-0.23, -0.03]
  1 study · 53 participants
  GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes low birth weight < 2500 g compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  RR 1.39 [0.92, 2.09]
  1 study · 756 participants
  Very low

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  Not pooled. Pirie 2013 (99 participants): mean difference in birth weight -0.07 kilograms. Macones 2010 (756 participants): difference in mean birth weight -67.7 grams.
  2 studies
  GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes gestational age (preterm birth < 37 weeks) compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes

  SRP + antimicrobial vs alternative mechanical treatment + placebo
  RR 1.40 [0.67, 2.92]
  1 study · 243 participants
  Very low
• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes

  SRP vs alternative mechanical treatment
  RR 0.87 [0.46, 1.67]
  4 studies · 1168 participants
  Very low
• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes

  SRP + antimicrobial vs SRP + placebo
  RR 3.08 [1.15, 8.20]
  1 study · 243 participants
  Very low

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

The review found no eligible studies for this question.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  Pre-eclampsia: Not reported for this comparison.
  0 studies
  No studies found

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes perinatal mortality (including fetal and neonatal deaths up to the… compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  RR 1.06 [0.60, 1.85]
  2 studies · 855 participants
  Very low

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes low birth weight < 1500 g compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  RR 1.85 [0.69, 4.96]
  1 study · 756 participants
  Very low

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Periodontal treatment (scaling and root planing, alone or with… led to lower bleeding on probing compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  MD -28.00 [-38.54, -17.46]
  1 study · 53 participants
  GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

The review found no eligible studies for this question.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  Maternal mortality: Not reported for this comparison.
  0 studies
  No studies found

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Periodontal treatment (scaling and root planing, alone or with… showed no clear difference in gingival index compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  MD -28.00 [-144.13, 88.13]
  1 study · 53 participants
  GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

The review found no eligible studies for this question.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  Adverse effects of therapy: Not reported for this comparison.
  0 studies
  No studies found

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  Preterm births < 35 weeks reported in four studies across three subcomparisons; none of the subcomparisons showed a difference; SRP versus alternative mechanical treatment not pooled due to considerable heterogeneity;…
  4 studies
  Very low

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Periodontal treatment (scaling and root planing, alone or with… led to lower probing depth compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  MD -0.93 [-1.12, -0.74]
  1 study · 53 participants
  GRADE not reported

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

The review found no eligible studies for this question.

• Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
  Small for gestational age: Not reported for this comparison.
  0 studies
  No studies found