Findings

What do systematic reviews say?

25 questions · 26 findings · 5 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 1 · 3.8%GRADE not reported 0 · 0%Very low 3 · 11.5%Low 3 · 11.5%Moderate 13 · 50%High 6 · 23.1%

Imiquimod vs placebo

HPV DNA persistence · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to lower HPV DNA persistence compared with placebo (high certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 0.43 [0.26, 0.72]
1 study · 47 participants
High

Imiquimod vs placebo

Pain ‐ Any grade · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to higher pain ‐ any grade compared with placebo (high certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 3.43 [1.8, 6.52]
1 study · 52 participants
High

Imiquimod vs placebo

Dose reductions · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod leads to higher dose reductions compared with placebo (high certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 7.77 [1.61, 37.36]
2 studies · 83 participants
High

Imiquimod vs cidofovir

Response to treatment at 6 months ‐ overall response · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in response to treatment at 6 months ‐ overall response compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 0.92 [0.73, 1.18]
1 study · 180 participants
Moderate

Intervention not reported

Recurrence rate at 1 year · women with high‐grade VIN

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions for high‐grade vulval intraepithelial neoplasia 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found