Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

273 questions · 288 findings · 36 reviews · All outcomes

No studies found 78 · 27.1%GRADE not reported 131 · 45.5%Very low 51 · 17.7%Low 20 · 6.9%Moderate 8 · 2.8%High 0 · 0%

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
Show 2 more findings

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Overall survival, induction cisplatin + 5-fluorouracil + docetaxel prior to concurrent chemoradiation (cisplatin) vs concurrent chemoradiation (cisplatin) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction cisplatin + 5-fluorouracil + docetaxel… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).

1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower locoregional control, induction cisplatin + 5-fluorouracil +… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.

1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Overall survival, induction platinum + 5-fluorouracil prior to radiotherapy vs radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (moderate certainty).

1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower disease-free survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.

1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Overall survival, induction cisplatin + 5-fluorouracil prior to concurrent chemoradiation (cisplatin) vs concurrent chemoradiation (cisplatin) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction cisplatin + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).

1 finding from 1 review

Preprosthetic surgery for a conventional denture (PPS) vs Implant retained overdenture (dental implants) (IRO)

Dissatisfied with eating with denture · Edentulous patients requiring improved denture retention

Preprosthetic surgery for a conventional denture (PPS) showed no clear difference in dissatisfied with eating with denture compared with implant retained overdenture (dental implants) (IRO); GRADE not reported.

1 finding from 1 review

Preprosthetic surgery for a conventional denture (PPS) vs Implant retained overdenture (dental implants) (IRO)

Dissatisfied with appearance of denture · Edentulous patients requiring improved denture retention

Preprosthetic surgery for a conventional denture (PPS) showed no clear difference in dissatisfied with appearance of denture compared with implant retained overdenture (dental implants) (IRO); GRADE not reported.

1 finding from 1 review

Preprosthetic surgery for a conventional denture (PPS) vs Implant retained overdenture (dental implants) (IRO)

Overall denture satisfaction (0-10 scale) · Edentulous patients requiring improved denture retention

Preprosthetic surgery for a conventional denture (PPS) led to lower overall denture satisfaction (0-10 scale) compared with implant retained overdenture (dental implants) (IRO); GRADE not reported.

3 findings from 1 review

Preprosthetic surgery for a conventional denture (PPS) vs Implant retained overdenture (dental implants) (IRO)

Dissatisfied with speech with denture · Edentulous patients requiring improved denture retention

Preprosthetic surgery for a conventional denture (PPS) showed no clear difference in dissatisfied with speech with denture compared with implant retained overdenture (dental implants) (IRO); GRADE not reported.

1 finding from 1 review

Preprosthetic surgery for a conventional denture (PPS) vs Implant retained overdenture (dental implants) (IRO)

Altered chin or lower lip skin sensation (binary) · Edentulous patients requiring improved denture retention

Preprosthetic surgery for a conventional denture (PPS) led to lower morbidity: altered sensation of the lower lip and chin compared with implant retained overdenture (dental implants) (IRO); GRADE not reported.

1 finding from 1 review

Preprosthetic surgery for a conventional denture (PPS) vs Implant retained overdenture (dental implants) (IRO)

Dissatisfied with lower denture · Edentulous patients requiring improved denture retention

Preprosthetic surgery for a conventional denture (PPS) showed no clear difference in dissatisfied with lower denture compared with implant retained overdenture (dental implants) (IRO); GRADE not reported.

1 finding from 1 review