Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

171 questions · 175 findings · 13 reviews · Haematology

No studies found 43 · 24.6%GRADE not reported 18 · 10.3%Very low 40 · 22.9%Low 40 · 22.9%Moderate 26 · 14.9%High 8 · 4.6%

Thrombopoietin mimetics vs placebo or usual care

Number of participants with severe or life‐threatening bleeding · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether thrombopoietin mimetics changes number of participants with severe or life‐threatening bleeding compared with placebo or standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with at least 1 bleeding episode · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether the intervention changes number of participants with at least 1 bleeding episode (very low certainty).

1 finding from 1 review

Plerixafor vs placebo

Mortality (12 months) · People with haematopoietic stem cell mobilisation for autologous transplantation in malignant lymphoma or multiple myeloma

Plerixafor showed no clear difference in mortality (12 months) compared with placebo (moderate certainty).

1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of participants with at least 1 bleeding episode · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Bleeding: Number of days on which a significant bleeding event occurred3 · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of participants with severe or life‐threatening bleeding · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation

Therapeutic or non‐prophylactic platelet transfusion showed no clear difference in number of participants with severe or life‐threatening bleeding up… compared with prophylactic platelet transfusion (low certainty).

1 finding from 1 review